Fast boats leave every day from Phnom Phen around 1 pm daily. They arrive in Chau Doc five hours later.
Chau Doc is on the border between Cambodia and Vietnam.
There is also a bus, but taking the Mekong River seems like the best option by far.
No need to worry about landslides everywhere, either. When I was along the Mekong (China side) we ran across several landslides and some big delays.
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